What is the mechanism of action of Osimertinib and how does it work?

Osimertinib is a tyrosine kinase inhibitor used to treat patients with non-small cell lung cancer who have been found to have certain abnormal epidermal growth factor receptor (EGFR) genes by a U.S. Food and Drug Administration (FDA) test.

Osimertinib helps prevent the recurrence of lung cancer in patients with EGFRexon19 deletion or exon21 L858R mutation after surgical resection of the tumor. As first-line treatment for patients with EGFRexon19 deletions or exon21 L858R mutations when the cancer has spread to other parts of the body (metastatic). People with the EGFR T790M mutation occur when the lung cancer has spread to other parts of the body (metastatic) and previous treatments with EGFR tyrosine kinase inhibitor (TKI) drugs have failed or are no longer effective.

Osimertinibis an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is used with first-line EGFR-TKIs in non-small cell lung cancer (NSCLC) ) that combine with certain mutated forms of EGFR (T790M, L858R and exon 19deletions) that predominate in tumors. As a third-generation tyrosine kinase inhibitor, Osimertinib is specific for the gatekeeper T790M mutation, which increases the binding activity of ATP to EGFR, leading to poor prognosis in advanced disease. Additionally, osimertinib has been shown to avoid wild-type EGFR during treatment, thereby reducing nonspecific binding and limiting toxicity. Compared with wild-type EGFR, osimertinibhas a L858R/T790M mutationThe affinity of EGFRmolecules is high200 times in vitro. Generic medicines cost several hundred yuan per box, and prices vary depending on the version. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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