When is the best time to take the targeted drug osimertinib?

Osimertinibis a cancer drug that interferes with the growth and spread of cancer cells in the body. Osimertinib(Osimertinib) is used to treat non-small cell lung cancer that is positive for the abnormal “EGFR” gene. Doctors will test for this gene. Osimertinib is sometimes used when the cancer has spread to other parts of the body (metastatic), or to help prevent the lung cancer from coming back after surgery to remove the tumor.

Osimertinib is recommended to be taken at the same time every day and can be taken with a meal or on an empty stomach. The most common (》20%) adverse reactions (including laboratory abnormalities) with osimertinib include leukopenia, lymphopenia, thrombocytopenia, diarrhea, anemia, rash, musculoskeletal pain, nail toxicity, neutropenia, dry skin, stomatitis, fatigue, and cough. The plasma protein binding rate of osimertinib is 95%. Osimertinib is metabolized to at least two pharmacologically active metabolites, AZ7550 and AZ5104, whose circulating concentrations are approximately 10% of the parent compound. Biochemical analysis showed that AZ7550 had similar potency and efficacy to osimertinib, while AZ5104 was more effective against mutant and wild-type EGFR. The main metabolic pathways are oxidation (mainly via CYP3A) and dealkylation. Osimertinibis mainly excreted through feces (68%), followed by urine (14%), and only 2% is excreted unchanged. The estimated mean half-life in the population is 48 hours. Oral clearance rate14.3liters/ hours. Generic drugs cost several hundred yuan per box. Different versions have different prices. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.