How long does it take for resistance to Osimertinib to develop? What to do after drug resistance?

Osimertinib is a targeted drug. Osimertinib is suitable for adjuvant treatment after tumor resection in adult patients with non-small cell lung cancer. The tumor has epidermal growth factor receptor (EGFR) exon19 deletion or exon 21 L858R mutation, indicated for the first-line treatment of adult patients with metastatic non-small cell lung cancer, indicated for the treatment of metastatic EGFR as detected by a U.S. Food and Drug Administration (FDA)-approved test Adult patients with T790M mutation-positive non-small cell lung cancer whose disease has progressed during or after treatment with an EGFR tyrosine kinase inhibitor (TKI).

The resistance time to osimertinib varies from person to person, and the time to develop resistance varies with the patient's constitution and condition. The resistance time to osimertinib is about 10 months to 1 years, and a small number of patients will not become resistant until about two or three years. After patients develop resistance to osimertinib, they can also choose other treatment methods such as chemotherapy, immunotherapy, and targeted drugs.

Osimertinib can bind toT790Mmutation-positiveEGFR protein, it can also bind toL858R Mutation-positive EGFR binds to and inactivates the 19 exon of EFGR. The absorption and metabolism process of osimertinib in the body follows linear pharmacokinetics. The time to reach peak plasma concentration is approximately 6 hours, the half-life is approximately 48 hours, and the clearance rate is 14.2L/h. After metabolism by the liver, 68% of the original drug is excreted in feces, and 14% is excreted in urine. Generic drugs cost several hundred yuan per box. Different versions have different prices. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.