How effective are palbociclib/palbociclib/palbociclib?

Palbociclib is an anti-tumor drug used to treat hormone receptor(HR) positive, human epidermal growth factor receptor2 Adult patients with (HER2)negative advanced or metastatic breast cancer, combined with:an aromatase inhibitor as initial endocrine-based therapy or fulvestrant for the treatment of patients with disease progression after endocrine therapy.

Growth of hormone receptor-positive breast cancer depends on cyclin-dependent kinases4 and 6 (CDK4 and CDK6), which promote the progression of the cell cycle from the G1 phase to the S phase. The efficacy of palbocicillin (an inhibitor of CDK 4 and CDK6) and fulvestrant in advanced breast cancer was evaluated. The Phase 3 study involved 521 patients with advanced hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer who had relapsed or progressed on prior endocrine therapy. The median progression-free survival for palbocicillin-fulvestrant was 9.2 months and for placebo-fulvestrant was 3.8 months. Palbocicillin-The most common grade 3 or 4 of fulvestrant The adverse event was neutropenia(62.0% vs. placebo-fulvestrant 0.6% ), leukopenia(25.2% vs. 0.6%), anemia(2.6%vs.1.7%), thrombocytopenia(2.3%vs0%)and fatigue (2.0% vs. 1.2%). Febrile neutropenia has been reported in 0.6% of palbocicillin-treated patients and in 0.6% of placebo-treated patients. The discontinuation rate due to adverse events was 2.6% in the palbocicillin group and 1.7% in the placebo group. CONCLUSIONS: In patients with hormone receptor-positive metastatic breast cancer who had disease progression on prior endocrine therapy, palbocicillin plus fulvestrant resulted in longer progression-free survival than fulvestrant alone. Original drugs in Hong Kong cost around 1 million, while generic drugs cost around 7more than 7more than 4 more than 1,000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.