How long should I take Palbociclib/Palbociclib?

Palbociclib is a cyclin-dependent kinase4/6 inhibitor. Palbociclib is combined with an aromatase inhibitor. It is suitable for the initial treatment of hormone receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative advanced or metastatic breast cancer in postmenopausal women or men. In combination with fulvestrant for the treatment of patients with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer whose disease has progressed after endocrine therapy.

For initial treatment of advanced breast cancer, 125 mg once daily on days 1-21 of each 28 day cycle in combination with an aromatase inhibitor. In the primary efficacy study, treatment was continued until disease progression or unacceptable toxicity. For previously treated advanced breast cancer, once daily on days 1-21 of each 28-day cycle125 mg, combined with fulvestrant500 on days 1 and 15 of cycle 1 mg, then on day 1 of each 28 day cycle thereafter. In the primary efficacy study, treatment was continued until disease progression or unacceptable toxicity.

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