Palbociclib/Pabociclib/Palbociclib Actions and Efficacy

Palbociclib is a CDK 4/6 inhibitor . Palbociclib is used to treat patients with hormone receptor (HR) positive, human epidermal growth factor receptor 2 Adult patients with (HER2)negative advanced or metastatic breast cancer. It is always used in combination with another drug:An aromatase inhibitor as initial endocrine therapy in postmenopausal women or men or fulvestrant in patients whose disease has progressed after endocrine therapy.

A phase 2 study showed that palbocicillin plus letrozole resulted in longer progression-free survival than letrozole alone as initial treatment for postmenopausal women with estrogen receptor (er)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. < Median progression-free survival in the palbocicillin-letrozole arm was 24.8 months (95% confidence interval, 22.1 to not estimable). 95%The confidence interval is 0.46 to 0.72; P<0.001). The most common grade 3 or grade 4 adverse event was neutropenia (which occurred in 66.4% of patients in the palbocicillin-letrozole group). Among patients, compared with 1.4%) in the placebo-letrozole group, leukopenia(24.8% vs. 0%) and anemia(5.4%than 1.8%)and fatigue (1.8%than 0.5%). Febrile neutropenia was reported in 1.8% of patients in the palbocicillin-letrozole group and in none of the patients in the placebo-letrozole group. Any permanent discontinuation of study treatment due to adverse events occurred in 43 patients (9.7%) in the palbocicillin-letrozole group (9.7%) span> and placebo-13 patients (5.9%) in the letrozole group.

Conclusion:In previously untreated ER positive, HER2 negative Among patients with advanced breast cancer, treatment with palbocicillin combined with letrozole resulted in significantly longer progression-free survival than letrozole alone, despite a higher incidence of myelotoxic reactions with palbocicillin combined with letrozole. Original drugs in Hong Kong cost about 1 or so, and generic drugs cost about 7 more than 7 more than 4 more than 1,000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.