How to take bosutinib

The recommended dose of BosutinibBosutinib is taken orally once daily with a meal. Tablets should be swallowed whole and not broken or cut. Treat until disease progression or intolerance to treatment. If a dose is missed by more than 12 hours, the patient should skip the dose and take the usual prescribed dose the next day.

(1) Newly diagnosed chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+CML):The recommended dose of bosutinib is 400 mg taken orally once daily with food.

(2) Patients with chronic phase, accelerated phase (AP) or blast phase (BP) Ph+CML, or resistance or intolerance to previous treatment:The recommended dose of bosutinib is 500 mg once daily, taken orally with food.

In clinical studies in adults with Ph+CML, dose increases in increments of 100 mg once daily to a maximum of 600 mg once daily are allowed for patients who do not achieve or maintain a hematological, cytogenetic, or molecular response and who do not experience grade 3 or higher adverse reactions at the recommended starting dose.

The originator drug of bosutinib is not marketed in the country, so it cannot be included in medical insurance. Currently, the original drugs sold overseas include Turkish version and European version. The price of the Turkish version may be more than RMB 2,000 per box of 500mg*28, and the price of the European version may be more than RMB 30,000 (the price may fluctuate due to the exchange rate). There are also bosutinib generic drugs produced overseas in other countries. Their pharmaceutical ingredients are basically the same as those of the original drug. The price of 500mg*30 per box may be more than 2,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.