What should I do if I develop resistance to bosutinib?

If resistance develops after using Bosutinib (Bosutinib), it is recommended that the patient consult a professional doctor or oncologist immediately. Everyone's constitution is different and their resistance to drugs is also different. Doctors will evaluate the patient's condition based on the specific situation and recommend an appropriate treatment plan. Here are some possible measures your doctor may consider:

1. Increase the dose: Doctors may adjust the drug dose to increase the inhibitory effect on cancer cells. However, this only works for some patients, so follow your doctor's advice.

2. Switch treatment options: If you are resistant to bosutinib, your doctor may recommend that you try other targeted therapies or chemotherapy options. Choosing an appropriate treatment regimen requires comprehensive consideration of factors such as the patient's condition, resistance mechanisms, and available treatment options.

3. Participate in clinical trials: In some cases, your doctor may recommend that you participate in clinical trials of new drugs to find more effective treatments. Participation in clinical trials requires a full understanding of the associated risks and benefits and decision-making under the guidance of a physician.

The originator drug of bosutinib is not marketed in the country, so it cannot be included in medical insurance. Currently, the original drugs sold overseas include Turkish version and European version. The price of the Turkish version may be more than RMB 2,000 per box of 500mg*28, and the price of the European version may be more than RMB 30,000 (the price may fluctuate due to the exchange rate). There are also bosutinib generic drugs produced overseas in other countries. Their pharmaceutical ingredients are basically the same as those of the original drug. The price of 500mg*30 per box may be more than 2,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.