Who is the manufacturer of Serputinib/Serpatinib?

Selpercatinib (Selpercatinib), the original researcher and manufacturer of this drug is the well-known Eli Lilly and Company, that is, Eli Lilly and Company. It was known under the code name LOXO-292 and has multiple trade names, such as Retsevmo, Ruituo and RETEVMO. Seputinib is known for its excellent central nervous system (CNS) activity, high selectivity for RET kinase, and potent potency. However, like many drugs, seputinib may affect both tumor cells and healthy cells during treatment, causing a series of side effects. Notably, alterations in RET drivers are largely mutually exclusive with other oncogenic drivers.

Seputinib is an oral prescription drug that has been strictly approved by the Food and Drug Administration (FDA). Its recommended dosage varies according to the patient's weight: patients weighing less than 50 kg are recommended to take 120 mg daily, while patients weighing more than 50 kg are recommended to take 160 mg daily. Both doses are administered in two divided doses daily until the patient's disease progresses or intolerable toxicity occurs. Seputinib has demonstrated significant efficacy in the treatment of multiple cancers involving RET gene mutations, including RET fusion-positive non-small cell lung cancer, RET-mutated medullary thyroid carcinoma and thyroid cancer, and other RET fusion-positive solid tumors.

Up to now, the original drug is sold in China as Seputinib, but it is not included in medical insurance. The price of each box of specifications80mg*56 capsules may be more than 10,000 yuan. There are European and American versions of the original drugs sold overseas, with the price of each box ranging from 20,000 to more than 100,000 yuan (prices may fluctuate due to exchange rates). Already available overseasSeputinibGeneric drugs are on the market, and their drug ingredients are basically the same as those of original drugs sold domestically and abroad. For example, the specifications produced by Laos Pharmaceutical FactoryThe price of each box of 40mg*120 tablets is more than 4,000 yuan (the price may fluctuate due to the exchange rate).