Detailed interpretation of lenvatinib patient medication guide

Lenvatinib, as a targeted therapy drug, is widely used in the treatment of malignant tumors such as advanced thyroid cancer and liver cancer. This guide will provide you with detailed dosing information about lenvatinib to help you better understand and use this medicine.

1. Drug treatment scope

Lenvatinib is mainly used to treat malignant tumors such as advanced thyroid cancer and liver cancer. It inhibits the vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR), cutting off the blood supply and growth signals of tumors, thereby effectively controlling the growth and spread of tumors.

2. Principle of drug action

Lenvatinib is a multi-target inhibitor that can effectively block targets such as VEGFR and FGFR. By inhibiting the activation of these receptors, it blocks the angiogenesis and growth signaling of tumor cells, thereby inhibiting tumor growth and spread.

3. Drug properties and uses

Lenvatinib is rapidly absorbed after oral administration, and the time to reach peak plasma concentration is approximately 1 to 4 hours. The drug is mainly metabolized in the liver and excreted through the liver and kidneys. The half-life is 5 to 10 hours. Two of its main metabolites are pharmacologically active and play a key role in the efficacy of the drug.

4. Taking suggestions

1.Differentiated thyroid cancer: Recommended dose24mg.

2.Renal cell carcinoma: Recommended dose18mg.

3.Hepatocellular carcinoma: weight60kg and above12mg; those weighing less than60kg8mg.

4.The best time to take the medicine is after meals to reduce gastrointestinal discomfort. Dosage adjustments should be made according to physician recommendations.

5. Possible adverse reactions

Common side effects include gastrointestinal discomfort (such as nausea, vomiting, loss of appetite, diarrhea), hand-foot syndrome (redness, swelling, pain in the hands and feet), high blood pressure, and thyroid dysfunction.

6. Precautions during use

1.People with impaired liver function need to adjust the dosage or frequency of medication.

2.People with a history of cardiovascular disease should closely monitor blood pressure and electrocardiogram.

3.Patients with impaired renal function may need to adjust the dose or medication interval.

7. Taboo situations

It is contraindicated if you are allergic to any component of lenvatinib.

8. Interactions between drugs

Lenvatinib may interact with other drugs (such as anticoagulants, chemotherapy drugs). Inform your doctor of all medications you are taking.

9. Suggestions for use by special groups

1.Pregnant women should use with caution, and lactating women should not use it.

2. Elderly patients should use it with caution and the dose may need to be adjusted.

3.The safety and effectiveness of this medication in children have not been established.

10. Purchase information

Lenvatinib is currently on the market in China and has been included in medical insurance. Patients can purchase it domestically. Please consult the local hospital pharmacy for specific prices. There are original drugs and generic drugs abroad. The original drugs are mainly Japanese original drugs, and the price is more than 1,000 yuan. Generic drugs sold abroad are relatively cheap, such as the Lao and Bangladeshi versions, which cost around a few hundred yuan. The ingredients of original drugs and generic drugs are basically the same.

Patients should read the instructions carefully before using lenvatinib and strictly follow the doctor's instructions. If you have any discomfort or questions, please consult your doctor promptly.