Instructions for use of Ixazomib Citrate Capsules

Ixazomib citrate is an antineoplastic drug that is primarily indicated in combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

Ixazomib citrate should be taken at least 1 hour before a meal or at least 2 hours after a meal to ensure optimal absorption of the drug. The recommended starting dose is 4 mg each time, on 28 day 1< of the treatment cycle span>, 8 and 15 days, 1 time per week. Take the whole capsule with water. Do not crush, chew or open the capsule to avoid affecting the effect of the medicine.

For patients older than65 years, dosage adjustment is usually not required, but their physical condition and drug response should be closely monitored. Patients with mild hepatic impairment do not need to adjust the dose; for patients with moderate to severe hepatic impairment, it is recommended to reduce the dose to 3mg. Patients with mild or moderate renal impairment do not need to adjust the dose; for patients with severe renal impairment or end-stage renal disease requiring dialysis, it is recommended to reduce the dose to 3 mg.

Blood tests and liver function tests should be performed regularly during treatment to monitor the effects of the drug on the body. Pay attention to observe whether serious adverse reactions occur, such as allergic reactions, reversible posterior encephalopathy syndrome, thrombocytopenia, etc. If found, seek medical treatment in time. Inform your doctor of all drugs you are taking, especially drugs that may affect the metabolism of ixazomib or increase the risk of adverse reactions.

Male and female patients of childbearing potential must use effective contraception during and for 90 days after treatment, as ixazomib may reduce the efficacy of oral contraceptives when coadministered with dexamethasone. Ixazomib citrate capsules should be stored in the original packaging at 2℃-30℃, away from moisture and direct sunlight. Please keep it out of reach of children to avoid accidental ingestion.