How much does a box of platinib cost?

Platinib is already on the market in the country, but it has not yet been included in medical insurance. The latest domestic price is around 30,000 to 60,000 yuan. There are two types of overseas original drugs, the European version and the American version. The latest price of the former is more than 40,000 yuan, and the latest price of the latter is around 16 yuan. In addition, the generic version of Platinib from Lucius in Laos has been approved by the Ministry of Health for marketing. Patients should choose to purchase according to their own needs. Overseas drugs must be purchased through formal and legal overseas channels to avoid buying counterfeit and shoddy drugs that may affect the health and safety of patients.

Platinib is a highly efficient and highly selective receptor tyrosine kinaseRET (Rearranged during Transfection) inhibitor. The drug was developed by Blueprint Medicines, which has exclusive rights to develop and commercialize it in Greater China. The main mechanism of action of platinib is to inhibit the phosphorylation of RET and its downstream molecules, thereby effectively inhibiting the proliferation of cells expressing RET gene mutations.

Platinib is an oral drug with a recommended dose of 400mg once a day on an empty stomach (do not eat at least 2 hours before taking it and at least 1 hours after taking it). Continue treatment until disease progression or unacceptable toxicity. If you miss a dose, take it as soon as possible that day and resume your regular daily dosing schedule the next day.

Platinib has shown certain adverse reactions in clinical trials, but most of them are grade 1 or grade 2, mainly including fatigue, constipation, diarrhea, high blood pressure, cough, fever, etc. Common grade 3～4 adverse reactions include hypertension, pneumonia, etc. Patients need to closely monitor their body's reaction during taking it and adjust their treatment plan under the guidance of a doctor.