How much does Ensidipine cost?

Enasidenib (Enasidenib), as a new targeted therapy drug, is currently not covered by medical insurance in China, so many patients can only purchase it through formal overseas channels. It is worth noting that there are legal versions of generic drugs on the overseas market, including the Lao version and the Bangladeshi version. Their drug ingredients are basically the same as the original drugs, and the current price is roughly between 2000 to 5000 yuan.

Ensidipine is mainly used to treat acute myeloid leukemia (AML), especially those carrying IDH2 gene mutations. IDH2 (isocitrate dehydrogenase2) has an important physiological function in normal cells. It is involved in converting isocitrate into α< The process of span>-ketoglutarate, a crucial step in cellular metabolism, also helps produceNADPH, a reducing agent that is essential for cells to defend against oxidative stress. However, in some patients with AML, IDH2 is mutated, significantly altering its function. This mutation causes cancer cells to convert α-ketoglutarate into 2-hydroxyglutarate (2-HG), and this metabolite has been proven to promote tumor growth and interfere with normal cell differentiation, proliferation and apoptosis, thus accelerating the development of cancer.

In clinical studies, ensidipine has shown significant efficacy in patients with AML carrying IDH2 mutations. The results of multiple clinical trials have shown that the drug can significantly improve the response rate and prolong the survival of such patients. At the same time, ensidipine also performed well in terms of safety and tolerability. Nonetheless, the use of any medication may be associated with certain side effects. For ensidipine, patients may experience mild adverse reactions during treatment, such as nausea, vomiting, diarrhea, and decreased appetite. In addition, some patients may experience abnormalities in biochemical indicators such as elevated bilirubin. However, it is good to know that most adverse reactions can be alleviated by adjusting drug dosage, monitoring relevant indicators, or taking symptomatic treatment measures.