The latest price of sparsentan/sparsentan in 2025

Sparsentan is a drug used to reduce the increase in protein in the urine of patients with primary immunoglobulin A nephropathy (IgA nephropathy). IgA nephropathy is a disease in which IgA is deposited in the kidneys and causes inflammation, leading to impaired kidney function. Sparsentan is an endothelin and angiotensin II receptor antagonist and works by blocking two substances that play important roles in the progression of kidney disease.

Sparsentan is available as an oral tablet and is usually taken once before breakfast or dinner. It is recommended to take it at the same time each day to ensure the effectiveness of the drug. Patients should follow the directions on the prescription label and consult their doctor or pharmacist for more information if necessary. When in use, the tablets should be swallowed whole and avoid splitting, chewing or crushing. Doctors may give a low dose initially and gradually increase the dose after 14 days depending on the patient's condition.

Although sparsentane can effectively control proteinuria caused by IgA nephropathy, it cannot cure the disease. Patients should continue to take the drug even if they feel well, and do not stop taking the drug without communicating with the doctor. When using sparsentan, there is a risk of hypotension, so patients are advised to maintain adequate fluid intake while taking the drug to prevent hypotension.

The original drug of sparsentane is not currently on the market in the country, so the price has yet to be determined. This drug has not been on the market for a long time overseas. The common specifications are 200mg and 400mg, with 30 tablets per box. The price of the European version may be higher than more than 40,000 yuan (actual price will be different due to the exchange rate), and the overall cost is relatively large. It is understood that generic drugs of sparsentan are also sold in overseas markets, and their ingredients are roughly the same as the original drug. For example, the price of 400mg products produced by a pharmaceutical factory in Laos may be around RMB 7,000 per box of 30 tablets (the price fluctuates with the exchange rate).

Reference materials:https://medlineplus.gov/druginfo/meds/a623018.html