How much does a box of axitinib/axitinib targeted drug cost in 2025?

Axitinib/Axitinib is a potent and selective second-generation vascular endothelial growth factor receptor (VEGFR) inhibitor that mainly targets VEGFR-1, VEGFR-2 and VEGFR-3. These receptors play a crucial role in tumor angiogenesis and growth. Therefore, axitinib can effectively prevent tumor progression by inhibiting the activity of these receptors. The drug has been approved in the United States, China and several other countries for the treatment of patients with advanced renal cell carcinoma who have failed one systemic therapy.

The recommended starting dose of axitinib is5 mg twice daily, and patients can choose to take it with or without food, which provides patients with flexibility. During clinical use, doctors can adjust the dosage according to the patient's tolerance and efficacy, allowing the dosage to be increased to a maximum of 10 mg twice daily, or the dosage to be reduced as needed. This flexible dose adjustment mechanism allows physicians to better optimize treatment regimens based on individual patient response.

Pharmacokinetic studies on axitinib show that the drug concentration shows a good proportionality relationship in the dose range of1-20 mg. This means that within the recommended clinical dose range, the absorption and elimination of the drug comply with linear pharmacokinetic characteristics, providing a reliable basis for its safety and effectiveness in clinical applications.

The original drug of axitinib has been launched in China and has been included in the reimbursement scope of Class B medical insurance. Common packaging specifications include1mg*14 tablets and 5mg*28 tablets, etc. The price of each box is about more than 2,000 RMB. In addition, the overseas original research version may be priced at about 6,000 yuan. At the same time, generic drugs of axitinib have also been launched in overseas markets. Their ingredients are almost the same as the original drug, including the Laos version, the Indian version and the Bangladesh version. The price is about 1,000 yuan (the price will change due to exchange rate fluctuations).

Reference materials:https://www.ema.europa.eu/en/medicines/human/EPAR/inlyta