How to correctly store larotrectinib (Vitaca) and its storage temperature requirements

Larotrectinib is a highly selective TRK inhibitor for the treatment of solid tumors harboring NTRK gene fusions. Since its ingredients are sensitive to temperature, humidity and light, correct storage is critical to ensuring the stability and efficacy of the drug. Improper storage conditions may cause drug degradation, thereby affecting the patient's therapeutic effect and even increasing the risk of adverse reactions.

According to the drug instructions, larotrectinib should be stored at a room temperature of about 25℃. The allowable fluctuation range is usually between 15℃ and 30℃. Avoid placing the medicine in an environment that is too hot or too cold, such as in a car or in the freezer of a refrigerator that is exposed to the sun in summer. Too high a temperature may accelerate the decomposition of drug ingredients, while too low a temperature may affect the solubility and stability of the drug, so maintaining a constant room temperature is the best way to store it.

Larotrectinib should be stored in the original sealed container to avoid prolonged exposure to air after disassembly. The medicine needs to be kept away from direct sunlight and humid environments, so it should not be placed in places prone to moisture such as kitchens and bathrooms. For oral solution dosage forms, they need to be used within a limited time after opening and stored according to the instructions. Generally, it is not recommended to refrigerate the product for a long time or expose it to high humidity.

When storing larotrectinib, patients are advised to keep the drug out of the reach of children and pets to avoid accidental ingestion. If the patient needs to travel long distances or carry medication, he should use a dry, light-proof medicine box and make sure it is placed in a cool and dry place. Do not leave it in a high temperature and direct sunlight environment. In addition, if the drug changes color, has an abnormal smell, or exceeds the expiration date, you should stop using it immediately and consult a doctor or pharmacist to avoid affecting the treatment effect.

Reference materials:https://www.drugs.com/