唑来膦酸注射液静脉滴注的副作用有哪些?

The side effects of intravenous infusion of zoledronic acid injection include the following aspects:

1. Systemic reactions: chest pain, fatigue, conjunctivitis, leg edema.

2. Digestive system: nausea, abdominal pain, dysphagia, anorexia, vomiting, constipation, diarrhea.

3. Cardiovascular system: hypotension.

4. Blood and lymphatic system: anemia, hypokalemia, granulocytopenia, thrombocytopenia, pancytopenia, hypomagnesemia, hypophosphatemia, and hypocalcemia.

5. Muscles and bones: joint pain, bone pain, and muscle pain.

6. Kidney: The creatinine value in serum increases (related to the time of administration).

7. Nervous system: insomnia, headache, drowsiness, anxiety, excitement.

8. Respiratory system: cough, pleural effusion, dyspnea.

Management of side effects of intravenous infusion of zoledronic acid injection

1. Systemic reaction: Observe changes in symptoms. If symptoms continue to worsen, the doctor should be notified in time. The dosage of the drug may need to be adjusted or the drug changed.

2. Digestive system: Patients are advised to choose light, easy-to-digest foods and avoid spicy, greasy and other irritating foods. If the symptoms are severe, drug treatment, such as antiemetics, laxatives, etc., may be considered under the guidance of a doctor.

3. Nervous system: It is recommended that patients maintain a good routine and mentality. If symptoms are severe, drug treatment may be considered under the guidance of a doctor, such as sleeping pills, anti-anxiety drugs, etc.

4. Respiratory system: If dyspnea, cough, or pleural effusion occurs, the doctor should be informed in time, and further examination and treatment may be required.

5. Blood system: Patients should undergo regular blood routine examinations in order to detect and deal with these side effects in a timely manner. If the symptoms are severe, blood transfusion, electrolyte supplementation and other treatments may be required under the guidance of a doctor.

6. Musculoskeletal system: It is recommended that patients take appropriate rest and avoid strenuous exercise. If symptoms are severe, drug treatment, such as analgesics, anti-inflammatory drugs, etc., may be considered under the guidance of a doctor.

7. Kidney function: Patients should undergo regular renal function tests. If creatinine is found to be elevated, the doctor should be informed in time, and kidney-preserving treatment may be required.

Contraindications and Precautions for Zoledronic Acid Injection

The levels of serum calcium, phosphorus, magnesium and serum creatinine should be closely monitored when used for the first time. If the levels of calcium, phosphorus and magnesium in the serum are too low, necessary supplementary treatment should be given.

If renal function worsens while receiving zoledronic acid injection, the drug should be discontinued until renal function returns to baseline.

Caution should be exercised when zoledronic acid injection is combined with nephrotoxic drugs.

It is prohibited for patients allergic to zoledronic acid injection or other bisphosphonic acid drugs.

Asthma patients who are allergic to aspirin should use zoledronic acid injection with caution.

Zoledronic acid injection is not recommended for patients with severe renal insufficiency.

Zoledronic acid injection is contraindicated in pregnant and lactating women.

Use zoledronic acid injection with caution in children. For more information about the precautions of zoledronic acid, please click: Read to learn.

Recommended hot articles: