柳氮磺吡啶对强直性脊柱炎有疗效吗？服药后会不会恶心？

Sulfasalazine, a sulfa drug that is not easily absorbed when taken orally, is decomposed and produces a weak antibacterial effect on intestinal flora. This drug can be used to treat inflammatory bowel disease and Crohn's disease, as well as rheumatoid arthritis. Today, let's learn in detail whether it is effective in ankylosing spondylitis? Will I feel sick after taking the medicine?

Sulfasalazine has antibacterial, antirheumatic and immunosuppressive effects. Trials have shown that sulfasalazine combined with leflunomide is effective in the treatment of ankylosing spondylitis. 72 patients with ankylosing spondylitis were randomly divided into a treatment group of sulfasalazine + leflunomide (LEF) and a control group of sulfasalazine + methotrexate. After 12 months of treatment, the effective rate of the sulfasalazine + LEF group was 94.44%, and the effective rate of the sulfasalazine + MTX group was 94.44%. 83.33%, there is no statistical significance in the overall efficacy difference between the two groups, which means that sulfasalazine + LEF has significant efficacy in the treatment of ankylosing spondylitis, has few adverse reactions, and is safe and tolerable. Sulfasalazine can reduce patients' tendinitis, synovitis, joint effusion, etc., so this drug is the first choice drug for the treatment of ankylosing spondylitis. It is also called a disease-modifying antirheumatic drug and is the anchor drug for ankylosing spondylitis.

However, there are side effects after taking sulfasalazine. Common nausea, vomiting, abdominal discomfort, sore throat, difficulty swallowing, and rare digestive system side effects such as pancreatitis, toxic hepatitis, and exacerbation of colitis. Fever and rash may also occur. In severe cases, it can cause skin necrosis (Lyell syndrome). This drug can also It can cause dysuria, crystalluria and hematuria, thrombocytopenia, leukopenia, megaloblastic anemia, etc. Therefore, nausea after taking the medicine is an adverse reaction. You should pay attention to your own changes during the medication. If an intolerance reaction occurs, you should contact the doctor in time and adopt a new treatment plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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