非布司他好用吗？

Is it useful? Febuxostat is a gout drug that has become a "new favorite" in recent years. Febuxostat applied for marketing in Japan in early 2004. In April 2008, the European Union first approved the marketing of febuxostat tablets, with specifications of 80 mg and 120 mg, and the trade name "Adenuric". It is used to treat chronic hyperuricemia with uric acid deposition (including patients with gout stones and/or gouty arthritis, or patients with a history of this). The FDA approved Febuxostat tablets for marketing in February 2009 for the long-term control of hyperuricemia in patients with gout. It was approved for sale in China in 2013. In the following years, it became the choice of more and more gout friends with its "better acid-lowering effect and higher safety".

Gout is a disease caused by disorders of purine metabolism. Generally speaking, in addition to the common hyperuricemia, there are also gouty acute arthritis, tophi deposition, tophi chronic arthritis, joint deformities, nephritis, and uric acid kidney stones. Hyperuricemia often refers to the situation where patients have fasting blood uric acid levels that are higher than normal under a normal purine diet. Patients may be asymptomatic, or may have conditions such as arthritis, gout, and high blood pressure.

Febuxostat is a xanthine oxidase (XO) inhibitor. Febuxostat is very effective in treating gout and can quickly reduce blood uric acid levels. Febuxostat is a selective xanthine oxidase inhibitor that has a specific uric acid-lowering effect without affecting other metabolic processes in the body.

It is a newly developed drug. At the same dose, febuxostat has a stronger effect in reducing blood uric acid. Therefore, when it comes to the choice of gout acid-lowering drugs, many patients prefer febuxostat. The recommended starting dose of febuxostat tablets is 40 mg. Once a day. If after 2 weeks. The blood uric acid level is still not less than 6 mg/dl (about 360 μmol/L). It is recommended that the dose be increased to 80mg. Once a day. When administering medication. There is no need to consider the effects of food and antacids.