非布司他效果如何？

(febuxostat) is a new, selective and novel non-purine xanthine oxidase (XO) inhibitor for use in patients with gout and hyperuricemia. Gout is a disease caused by disorders of purine metabolism. Generally speaking, in addition to the common hyperuricemia, there are also gouty acute arthritis, tophi deposition, tophi chronic arthritis, joint deformities, nephritis, and uric acid kidney stones. Hyperuricemia often refers to the situation where patients have fasting blood uric acid levels that are higher than normal under a normal purine diet. Patients may be asymptomatic, or may have conditions such as arthritis, gout, and high blood pressure.

How effective is febuxostat?

A multicenter, double-blind, randomized phase II clinical study evaluated the safety and efficacy of febuxostat (febuxostat) in gout. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or febuxostat (40, 80 or 120 mg/d). After 4 weeks, the test found that the serum uric acid concentration of patients in each dose group of febuxostat was significantly lower than before treatment. According to the dose, each group decreased by an average of 3. 7%, 44% and 59%, while patients in the placebo group only decreased by 2%; the vast majority of patients persisted in completing the trial. The incidence of adverse reactions in the febuxostat and placebo groups was similar, and most of these adverse reactions were mild and self-limiting, with common ones including diarrhea, pain, back pain, headache and joint pain.

Since its launch, febuxostat has quickly occupied the gout market with its good therapeutic effect and low side effects. Febuxostat can quickly reduce blood uric acid levels without affecting other metabolic processes in the body. However, the medical companion tour reminds patients that gout is a relatively common disease and the treatment cycle is relatively long. Therefore, during the treatment of gout disease, patients must follow the doctor's instructions and take the medicine patiently. They are not allowed to increase or decrease the dosage without permission to avoid causing other discomforts. For more information about febuxostat, please consult Medical Companion Travel.