feburic要吃多久？

(Febuxostat) is a xanthine oxidase (XO) inhibitor that binds to xanthine oxidase through a non-competitive mechanism to inhibit xanthine oxidase activity, thereby inhibiting the production of uric acid and achieving the purpose of reducing acidity.

It applied for listing in Japan in early 2004. In April 2008, the European Union first approved the marketing of febuxostat tablets, with specifications of 80 mg and 120 mg, and the trade name "Adenuric". It is used to treat chronic hyperuricemia with uric acid deposition (including patients with gout stones and/or gouty arthritis, or patients with a history of this). The FDA approved Febuxostat tablets for marketing in February 2009 for the long-term control of hyperuricemia in patients with gout. It was approved to be listed in China in 2013.

How long should I take feburic (febuxostat)?

The starting dose of febuxostat is 40 mg once daily. If the blood uric acid level is still not less than 6 mg/dl (approximately 360 μmol/L) after 2 weeks, it is recommended that the dose be increased to 80 mg once a day. Treatment should be continued until disease progression or intolerable toxicity occurs.

Food and antacid effects do not need to be considered when administering the drug. Patients with mild or moderate hepatic insufficiency (Child-Pugh classes A and B) do not need to adjust the dosage. Patients with severe hepatic insufficiency (Child-Pugh class C) should use febuxostat with caution.

Special populations: Patients with hepatic impairment: No dose adjustment is required for patients with mild or moderate hepatic impairment (Child-Pugh A, B). The efficacy and safety of feburic (febuxostat) in patients with severe hepatic insufficiency (Child-Pugh class C) have not been studied, so feburic (febuxostat) should be used with caution in these patients.

Patients with renal insufficiency: Patients with mild or moderate renal insufficiency (Clcr30-89 ml/min) do not need to adjust the dose. The recommended starting dose of feburic is 40 mg once daily. If the blood uric acid level is still not less than 6 mg/dl after 2 weeks, it is recommended that the dose be increased to 80 mg once a day. There are insufficient study data in patients with severe renal insufficiency (Clcr <30ml/min), so feburic (febuxostat) should be used with caution in these patients. Uric Acid Levels Two weeks after starting treatment with febuxostat, it is possible to assess whether the serum uric acid level has reached the target value (less than 6 mg/dl).