非布司他价格

以见效快、副作用少的特点，已成为目前治疗痛风的新型一线产品，由于非布司他在国内价格昂贵，很多患者只能望而却步，那么，非布司他仿制药价格是多少呢？

据医伴旅了解，印度Zydus药厂生产的非布索坦疗效与原研药一样，价格确低很多，规格为80mg*30片/盒，它的价格大概在200$左右，由于汇率浮动，价格不能精确，具体详细内容请咨询医伴旅。

In addition, patients are reminded that they should be aware of drug interactions when using febuxostat:

1. Hydrochlorothiazide: No dose adjustment required

Thiazide diuretics (hydrochlorothiazide, indopamide) can increase serum uric acid concentrations. Patients with hypertension and hyperuricemia should avoid taking thiazide diuretics as much as possible.

2. Azathioprine or mercaptopurine: combined use is prohibited

Febuxostat is a xanthine oxidase inhibitor that reduces serum uric acid concentration by inhibiting uric acid synthesis. Febuxostat may increase plasma concentrations of azathioprine or mercaptopurine, resulting in toxicity.

3. Theophylline: Monitor the blood concentration of theophylline

Febuxostat may increase the plasma concentrations of theophylline.非布司他对黄嘌呤氧化酶的抑制作用，可导致经尿排泄的1-甲基黄嘌呤（茶碱的一种主要代谢物）含量增大约400倍。

4. Statins: Pay attention to muscle toxicity

据文献报道，有3例患者常年服用他汀类降血脂药物（瑞舒伐他汀、阿托伐他汀和辛伐他汀各1例），在加用非布司他后出现横纹肌溶解症状，痊愈后再次服用他汀类药物均未复发。

Special reminder:

别嘌醇和非布司他属于抑制尿酸合成药，虽然不会增加尿液中尿酸浓度，但会增加尿液中次黄嘌呤和黄嘌呤浓度。 In order to prevent the formation of xanthine stones, you should increase your water intake and alkalize your urine if necessary while taking allopurinol.