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Tablets are commonly used drugs to treat gout. Gout patients must pay attention to keeping warm in daily life, get more rest, and take medication in time after the symptoms appear, because the initial treatment effect of the disease is relatively good. Although the therapeutic effect of febuxostat is good, there are some people who are suitable for it and some people who are not suitable for it. So, let’s take a look at the people who are suitable for febuxostat!

Indications for Febuxostat: Suitable for patients undergoing long-term treatment of hyperuricemia with gout symptoms!

People who are unwell with febuxostat:

1. It is not recommended for patients with asymptomatic hyperuricemia.

2. Breastfeeding women

Febuxostat is excreted in rat milk. It is unknown whether febuxostat is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when administering febuxostat to breastfeeding women.

2. Medication for children

The safety and effectiveness of febuxostat tablets in children under 18 years of age have not been determined.

3. Medication for the elderly

No dose adjustment is required when using Febuxostat tablets in elderly patients. Compared with other age groups, there are no clinically significant differences in safety and effectiveness, but it cannot be ruled out that some elderly patients are more sensitive to febuxostat tablets. The Cmax and AUC24 of febuxostat in elderly patients (≥65 years old) after multiple-dose oral administration are similar to those in younger patients (18-40 years old).

In addition, let us understand how febuxostat exerts its uric acid-lowering effect?

Uric acid is a product of purine metabolism in the body and is mainly excreted in the urine.

If for some reason, the production of uric acid increases and the excretion of uric acid decreases, uric acid will accumulate in the body.

The metabolism of purine into uric acid requires the participation of xanthine oxidase.

It is a new type of xanthine oxidase (XO) selective inhibitor that specifically hooks up with xanthine oxidase so that it cannot play a role in the process of metabolizing purine into uric acid, solving the root cause of the problem of high uric acid.