非布司他效果如何呢？

Currently, there is no designated drug for the complete cure of gout. They all control uric acid. From the perspective of Western medicine, high uric acid can only be controlled, not cured. Currently, there are several drugs on the market to treat gout. So, what is the therapeutic effect?

A multicenter, double-blind, randomized phase II clinical study evaluated the safety and efficacy of febuxostat in gout. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or febuxostat (40, 80 or 120 mg/d). After 4 weeks, the test found that the serum uric acid concentration of patients in each dose group of febuxostat was significantly lower than before treatment. According to the dose, each group decreased by an average of 3. 7%, 44% and 59%, while patients in the placebo group only decreased by 2%; the vast majority of patients persisted in completing the trial. The incidence of adverse reactions in the febuxostat and placebo groups was similar, and most of these adverse reactions were mild and self-limiting, with common ones including diarrhea, pain, back pain, headache and joint pain. 

A phase III clinical trial compared the efficacy of febuxostat (80 and 120 mg/d) and allopurinol (300 mg/d) in parallel. A 1-year study of 760 patients showed that compared with the allopurinol group, more patients in the febuxostat group achieved the main trial efficacy indicator - the sUA concentration was measured below 60mg/L in the last 3 months (all subjects were gout patients, and the sUA concentration before the trial was above 80mg/L).

After 52 weeks of treatment, febuxostat failed to significantly reduce the area of tophi (tophus is an aggregate of urate crystals unique to gout), but the effect was more obvious in the high-dose group early in the trial; in each treatment group, the sUA concentration reached the target (<60mg/ Patients with L) were less likely to have gout attacks again, and their tophi area was more significantly reduced; adverse reactions and their incidence rates were similar in each treatment group, including abnormal liver function, diarrhea, headache, joint-related signs and symptoms, and musculoskeletal/connective tissue symptoms.

From this, it is proved that the therapeutic effect is remarkable!