非布司他用量是多少呢？

It is an effective non-purine selective inhibitor of xanthine oxidase XO. By selectively inhibiting xanthine oxidase, it can achieve the therapeutic effect of reducing serum uric acid.

Uric acid is the end product of purine metabolism and is produced in the cascade reaction of hypoxanthine → xanthine → uric acid. Each step of the conversion is catalyzed by xanthine oxidase.

It has been shown that febuxostat can effectively inhibit oxidized and reduced xanthine oxidase, and its effect on the treatment of gout has also been verified. So, what is the dosage of febuxostat?

Febuxostat was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels.

Treat with febuxostat 40 mg/day for 6 months, and check the uric acid level regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body. 

After 6 months of treatment:

(1) If the blood uric acid level remains between 240 umol/l and 360 umol/l, maintain febuxostat 40 mg/day treatment.

  (2) If the blood uric acid level is higher than 360 umol/l, increase the dose of fexostatin by 60 mg/day, up to a maximum of 80 mg/day, and monitor blood uric acid, liver and kidney function regularly. 

(3) If the blood uric acid level is lower than 240 umol/l, the dose of febuxostat can be reduced to 20 mg/day and the treatment can be maintained for 6 months.

In addition, due to the different severity of the disease, the course of medication is also different, and the efficacy is also different. This needs to be analyzed on a case-by-case basis. If patients want to achieve better therapeutic effects, they must strictly cooperate with the doctor in treatment, so as to achieve better therapeutic effects and avoid some side effects. During treatment with tablets, patients must ensure a light diet and try to eat some nutritious foods.