非布司他疗效怎么样呢？

It is a xanthine oxidase and xanthine dehydrogenase inhibitor that can reduce uric acid and is used to treat gout patients with hyperuricemia. So, what is the therapeutic effect of febuxostat?

Febuxostat tablets are suitable for the long-term treatment of hyperuricemia in gout patients. Therefore, if gout patients develop hyperuricemia, they can be treated with febuxostat tablets for a long time, which will have a more prominent therapeutic effect. Febuxostat does not affect the synthesis and metabolism of other purine pyrimidines. It has the effect of strongly reducing uric acid and can exert high activity in small doses. It is relatively safe. It has accurate efficacy and good safety tolerance for patients who are not suitable for allopurinol treatment.

In the past 30 years, allopurinol has been the only clinical drug used to inhibit the production of uric acid. It has been widely used in clinical practice as a gold treatment drug for gout, and has achieved good results in the treatment of gout. Compared with allopurine, febuxostat has significant advantages:

(1) Allopurinol only inhibits the reduced form of XOR, while febuxostat has a significant inhibitory effect on both oxidized and reduced forms of XOR, so its effect in reducing Chemicalbook uric acid is more powerful and lasting;

(2) Since allopurinol is a purine analogue, it will inevitably affect the activities of other enzymes involved in purine and pyridine metabolism. Therefore, repeated high-dose administration is required to maintain high drug levels during allopurinol treatment. This also leads to serious or even fatal adverse reactions due to drug accumulation. Febuxostat is a non-purine XOR inhibitor and therefore has a better safety profile.

In addition, long-term application of febuxostat can maintain the blood uric acid in most patients at ≤6.0mg/dl for a long time, especially for patients with mild to moderate renal impairment. Febuxostat has no significant impact on the pharmacodynamics and pharmacokinetics, so its uric acid-lowering effect is no different from that of patients with normal renal function. It is also safe and safe, so patients can use it with confidence!