非布索坦可以根治痛风吗？

Can gout be cured? A patient recently asked. Let’s take a look.

A multicenter, double-blind, randomized phase II clinical study evaluated the safety and efficacy of febuxostat in gout. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or this product (40, 80 or 120 mg/d). After 4 weeks, tests found that the serum uric acid concentration of patients in each dose group of this product was significantly lower than before treatment. According to the dose, each group decreased by an average of 37%. %, 44% and 59%, while the patients in the placebo group only decreased by 2%; the vast majority of patients persisted in completing the trial. The incidence of adverse reactions in this product and the placebo group was similar, and most of these adverse reactions were mild and self-limiting, with common ones including diarrhea, pain, back pain, headache and joint pain.

Febuxostat cannot cure gout. It mainly selectively inhibits the production of epoxidase, thereby inhibiting the production of uric acid. It can reduce the level of uric acid in the blood. This drug is mainly used for symptomatic treatment and uric acid-lowering treatment. If gout cannot be treated from its cause, the purpose of cure will not be achieved. But this drug is also commonly used in our clinical practice to treat gout and stabilize uric acid. Gout is mainly caused by excessive blood uric acid in the body causing crystals in the joints. Mainly caused by the combined effects of genetics, environmental factors, etc. You must control your diet and avoid high-purine foods such as scallops, crabs, and shrimps, as well as laohuo soup, beer, etc. You can usually eat more low-fat milk and low-fat cheese in moderation to supplement protein. It is recommended that you eat more and drink more baking soda water, which will have a certain effect on improving the condition.

Febuxostat was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat 40 mg/day for 6 months, and check the uric acid level regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body.