非布索坦的售价是多少呢？

It is a xanthine oxidase (XO) inhibitor and is suitable for the long-term treatment of hyperuricemia with gout symptoms. Currently, there are three commonly used gout uric acid-lowering drugs in clinical practice: allopurinol, benzbromarone and febuxostat. Among them, febuxostat has the strongest uric acid-lowering effect and has relatively fewer side effects. Therefore, it has been welcomed by gout patients as soon as it was launched. Today let’s find out how much does Febuxostat cost?

Febuxostat was approved in 2009 for the treatment of chronic hyperuricemia. Compared with the traditional treatment drug allopurinol, febuxostat is more effective in reducing uric acid. The most common adverse reactions are abnormal liver function, diarrhea and rash. Medication guidelines recommend a starting dose of 40 mg/d. In patients with mild to moderate renal impairment (creatinine clearance [CrCl] 30-89 mL/min), the starting dose is the same as in patients with normal renal function.

  I believe that the majority of gout patients are also very concerned about the price of febuxostat. The price of the original drug in Japan is higher than that in India, about $1,500 per box. Febuxostat produced by Zydus Pharmaceutical Factory in India has the same efficacy as the original drug, but the price is indeed much lower. The specification is 80mg*30 tablets/box. Its price is about 200$. Due to the floating exchange rate, the price cannot be accurate. For specific prices, please consult the regular overseas medical service company Medical Travel.

Among drugs that inhibit uric acid production, colchicine is mainly used in the acute phase (acute phase). Compared with febuxostat, it is mainly allopurinol. Compared with allopurinol, febuxostat has the following advantages in addition to having fewer side effects:

1. Allopurinol only inhibits the reduced form of XOR, while febuxostat has a significant inhibitory effect on both oxidized and reduced forms of XOR, so its effect in reducing uric acid is more powerful and lasting;

  2. Since allopurinol is a purine analogue, it will inevitably affect the activities of other enzymes involved in purine and pyridine metabolism. Therefore, repeated high-dose administration is required to maintain high drug levels during allopurinol treatment. This also leads to serious or even fatal adverse reactions due to drug accumulation. Febuxostat is a non-purine XOR inhibitor and therefore has a better safety profile.

The above is the price content, I hope it can help you!