非布司他的注意事项有什么呢？

The starting dose is 40 mg/d. After taking this dose for 2 weeks, monitor the blood uric acid level. If the blood uric acid does not reach the standard, increase the dose to 80 mg/d. The usual dose is 40~120 mg/d. The efficacy of febuxostat 40 mg/d is equivalent to that of allopurinol 300 mg/d. Gout patients with mild to moderate renal insufficiency and mild hepatic insufficiency do not need to change the dosage of medication, but they also need to regularly monitor changes in liver and kidney indicators. Today we will learn about the precautions for febuxostat?

If side effects (such as nausea, vomiting, abdominal pain or loss of appetite, etc.) or weight loss occur during treatment, the daily dose should be reduced to a dose that the patient can tolerate. Maintenance dose: 1.5-6 mg/time, twice a day. Patients who obtain the best effect should maintain their highest and well-tolerated dose. The highest recommended dose: 6 mg/time, twice a day. 

Patients with reduced renal or hepatic function: Patients with reduced renal or hepatic function do not need to adjust the dose. Contraindications include patients with known allergies to rivastigmine bitartrate, other carbamic acid derivatives, or other formulation ingredients. Since no relevant research has been conducted. Exelon is contraindicated in patients with severe liver damage.

Febuxostat tablets are prescription drugs. In order to be safe and reduce adverse reactions, it is recommended that patients take them under the guidance of licensed physicians and pharmacists. Before taking the medicine, you need to read the instructions carefully to understand the taking method and contraindications of the medicine to avoid more adverse reactions and side effects. 

Gout attack: In the early stage of taking this product, gout attack may occur because the change in blood uric acid level causes the urate deposited in the tissue to be mobilized. To prevent gout attacks during the initial stages of taking febuxostat, it is recommended to take NSAIDs or colchicine at the same time. The benefits of preventive treatment can last up to 6 months. If gout attacks during treatment with febuxostat, there is no need to interrupt the medication. Gout should be treated accordingly based on the patient's individual circumstances. 

Febuxostat is an inhibitor of xanthine oxidase during the formation of uric acid. It can inhibit the production of uric acid, thereby reducing the concentration of blood uric acid. It is one of the most commonly used drugs to inhibit the production of uric acid. However, febuxostat has not been used for a long time. According to the current observed phenomenon, it seems to be more powerful than allopurinol in reducing uric acid levels.

The above is the content of the precautions, I hope it can help you!