非布司他治疗痛风效果怎么样？

How effective is febuxostat in treating gout? The trial explores the efficacy and safety of febuxostat (febuxostat, feburic) in the treatment of gouty arthritis.

Methods: The trial selected 80 patients with gouty arthritis admitted to the hospital for a group study. They were divided into an observation group and a control group by a random double-blind method. The control group was treated with allopurinol, and the observation group was treated with febuxostat (Febuxostat). The two groups were compared before treatment, serum uric acid, blood lipid indicators before and after treatment, color ultrasound performance before and after treatment, and adverse reactions at 2, 4, 8, 16, and 24 weeks of treatment.

The results showed that there was no significant difference in serum uric acid between the two groups before treatment. There was improvement at 2, 4, 8, 16, and 24 weeks after treatment, but the difference between the groups was not statistically significant, indicating that febuxostat (febuxostat, feburic) and allopurine have similar effects on improving serum uric acid levels. There was no difference in blood lipid indexes between the two groups before treatment. After treatment, the HDL of the observation group was higher than that of the control group. It can be seen that febuxostat treatment Treatment can better improve the patient's blood lipid index HDL; there is no significant difference in color ultrasound performance between the two groups before treatment. After treatment, the observation group's joint effusion, gout crystals, and synovial thickening are lower than those of the control group, indicating that febuxostat is more effective in improving patients' joint effusion, synovial thickening, and gout crystals. Both groups have adverse reactions, but the difference is not statistically significant, which shows that febuxostat treatment is safer.

Conclusion: The application of febuxostat (febuxostat, feburic) in the treatment of gouty arthritis has a significant effect in improving serum uric acid and blood lipid indicators. It can also improve color ultrasound performance, and is highly safe and worthy of application.

Although febuxostat (febuxostat, feburic) has a significant effect in treating gout, febuxostat is dose-dependent and is metabolized by the liver, which can easily cause liver damage and even induce recurrence of cardiovascular disease. For this reason, patients need to use febuxostat under the advice of a doctor.