非布司他（feburic）用法用量

Febuxostat (febuxostat, feburic) and allopurinol are both xanthine oxidase inhibitors, but their molecular structures are completely different from allopurinol and purine. They can combine with xanthine oxidase through a non-competitive mechanism, inhibit xanthine enzyme activity, and inhibit the production of uric acid.

What is the dosage of febuxostat (feburic)?

The recommended initial dose of febuxostat is 40 mg once a day (some foreign instructions recommend a starting dose of 20 mg, once a day). After taking the drug for 2 to 5 weeks, recheck the blood uric acid. Gradually increase the dosage according to the blood uric acid value, with each increment of 20 mg. The maximum daily dose is 80 mg. After the blood uric acid value reaches the target, maintain the lowest effective dose. Food and antacids have no effect on taking the medicine.

In the early stages of treatment, the rapid decrease in blood uric acid levels may cause more urate deposited in tissues to be mobilized, leading to an increase in the frequency of gout attacks.

In order to prevent gout attacks in the early stages of treatment, it is recommended to start with a small dose and gradually increase the dose, and use colchicine and non-steroidal anti-inflammatory drugs (such as ibuprofen, etc.) under the guidance of a doctor.

Patients with acute gout attacks need to control gout symptoms before using febuxostat. If gout attacks occur during treatment with febuxostat, there is no need to discontinue treatment with febuxostat. Gout should be treated accordingly based on the specific circumstances of the attack.

No dose adjustment is required in patients with mild or moderate renal impairment. The recommended starting dose of this product is 40 mg once daily. After a dose of 40 mg for two weeks, for patients whose serum uric acid level (sUA) is still higher than 6 mg/dl, the recommended dose is 80 mg.

Febuxostat is absorbed in the intestine after oral administration, with a bioavailability of 47%, a blood and plasma protein binding rate of 99.2%, and is mainly metabolized in the liver, with a half-life of 5 to 8 hours. It is metabolized in the liver into inactive substances, 49% is excreted through the kidneys, and 45% is excreted through the feces, which is a dual-channel excretion drug.