非布索坦有什么注意事项？

Febuxostat (febuxostat, feburic) belongs to the class of drugs that inhibit the production of uric acid. It is a new and highly effective selective inhibitor of non-purine xanthine oxidase (a key enzyme that promotes the production of uric acid). By acting highly selectively on this oxidase, it reduces the synthesis of uric acid in the body and lowers the concentration of uric acid, thereby effectively treating ventilation diseases. What are the precautions for Febuxostat?

Gout attacks: An increase in the frequency of gout attacks is common during the early stages of taking febuxostat. This is because blood uric acid concentration decreases, leading to mobilization of urate deposited in tissues. To prevent gout attacks during the initial stages of treatment, it is recommended to take nonsteroidal anti-inflammatory drugs or colchicine at the same time. If gout attacks during febuxostat treatment, there is no need to discontinue febuxostat treatment. Gout should be treated accordingly according to the patient's specific situation.

Cardiovascular events: In randomized controlled studies, patients treated with febuxostat had a higher rate of cardiovascular thrombotic events (including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke) than those treated with allopurinol, with febuxostat at 0.74/100 patient-years and allopurinol at 0.60/100 patient-years. A causal relationship between febuxostat and cardiovascular thrombotic events has not been established. Pay attention to monitor the symptoms and signs of myocardial infarction and stroke when taking the medication.

The U.S. Food and Drug Administration (FDA) issued a safety information warning for the gout drug febuxostat (febuxostat, feburic), believing that it increases the risk of cardiovascular death and all-cause death compared with another gout drug, allopurinol. Patients who have failed or are intolerant to allopurinol can still use febuxostat, but physicians should inform patients of the cardiovascular risks of febuxostat and advise them to seek immediate medical attention if they develop the following symptoms: chest pain, shortness of breath, fast or irregular heartbeat, numbness or weakness on one side of the body, dizziness, difficulty speaking, or sudden severe headache.