非布索坦的作用功效

(Febuxostat) is a selective inhibitor of non-purinic xanthine oxidase/xanthine dehydrogenase, which works by reducing blood urate concentration. Allopurinol is a purine analogue, which can affect the activity of other enzymes in purine and pyrimidine metabolism in the body, and is prone to some adverse reactions. The specificity of Febuxostat's inhibitory effect can avoid these possible adverse reactions, and it is clinically used to reduce blood uric acid in patients with gout.

It is understood that a study mainly evaluated the efficacy and safety of febuxostat (first-line urate-lowering drug) in patients with gout and hyperuricemia through a systematic review and analysis.

Research methods: A randomized controlled trial study on the efficacy and safety of Febuxostat (Febuxostat) in patients with gout and hyperuricemia. All statistical data were analyzed using RevMan 5.3. Heterogeneity analysis used the Q statistic and I2 test, and the outcome indicators were calculated with 95% confidence intervals. Two-sided tests were used for analysis, and P<0.05 was considered statistically significant. Study results: A total of 1317 participants. The results showed that the serum uric acid in the febuxostat treatment group was significantly lower than that in the control group. In addition, in patients with gout stages 3 and 4, the eGFR in the febuxostat (febuxostat) treatment group was significantly higher than that in the control group. There were no significant differences in serious complications or death between the treatment and control groups.

Analysis shows that Febuxostat (Febuxostat) not only has a uric acid-lowering effect, but also has a renal protective effect in patients with gout. Studies with larger sample sizes and higher quality are needed to further elucidate the role of febuxostat in the progression of gout. Compared with similar drugs for the treatment of gout, Febuxostat (Febuxostat) has high selectivity and stronger activity. Its efficacy is better than that of allopurinol, the current gold standard treatment drug for gout, and its efficacy is fast and its adverse reactions are mild.

The above are the functions and effects of (Febuxostat) provided by our medical companion tour.

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