非布索坦治疗痛风有效果没？

Is (Febuxostat) effective in treating gout? Febuxostat (Febuxostat) is a selective inhibitor of non-purinic xanthine oxidase/xanthine dehydrogenase. It works by reducing blood urate concentration. Allopurinol is a purine analogue that can affect the activity of other enzymes in purine and pyrimidine metabolism in the body and is prone to some adverse reactions. The specificity of Febuxostat's inhibitory effect can avoid these possible adverse reactions. It is clinically used to reduce blood uric acid in patients with gout.

Febuxostat (Febuxostat) was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat 40 mg/day for 6 months, and check the uric acid level regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body.

It is understood that a study mainly evaluated the efficacy and safety of febuxostat (first-line urate-lowering drug) in patients with gout and hyperuricemia through a systematic review and analysis. Research methods: A randomized controlled trial study on the efficacy and safety of febuxostat in patients with gout and hyperuricemia. All statistical data were analyzed using RevMan 5.3. Heterogeneity analysis used the Q statistic method and I2 test, and the outcome indicators were calculated with 95% confidence intervals. Two-sided tests were used for analysis, and P<0.05 was considered statistically significant. Study results: A total of 1317 participants. The results showed that the serum uric acid in the febuxostat treatment group was significantly lower than that in the control group. In addition, in patients with gout stages 3 and 4, the eGFR in the febuxostat treatment group was significantly higher than that in the control group. There were no significant differences in serious complications or death between the treatment and control groups.

Clinical trials have shown that Febuxostat (Febuxostat) not only has a uric acid-lowering effect, but also has a renal protective effect in patients with gout. Studies with larger sample sizes and higher quality are needed to further elucidate the role of (febuxostat) in the progression of gout.

Recommended related articles: