Desirox是什么药？

What kind of medicine is it? Desirox is an iron chelator product developed by the Swiss pharmaceutical company Novartis. It is the first oral iron chelator approved by the US FDA for routine use. It is used for patients with iron accumulation due to long-term blood transfusion (such as thalassemia or other rare anemias). It is suitable for children over two years old and adults.

Patients should note that deferasirox should be taken on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day. Tablets should not be chewed or swallowed whole. Deferasirox should not be taken with aluminum-containing antacids, and the dose (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

Deferasirox dispersible tablets (Enrige) are oral active chelating agents that are highly selective for iron (Fe3+). It is a ligand with 3 protrusions that binds iron with high affinity in a 2:1 ratio. Although deferasirox has a very low affinity for zinc and copper, serum concentrations of these trace metals decreased to varying degrees after administration. The clinical significance of these reductions in metal concentrations is unclear. After multiple doses, deferasirox exposure increased, with an accumulation factor of 1.3-2.3. The absolute bioavailability (AUC) of deferasirox (Enrige) orally dispersible tablets is approximately 70% of intravenous administration. Total exposure (AUC) increased approximately 1-fold when taken with a high-fat breakfast (fat content >50% of total calories) and approximately 50% when taken with a standard breakfast. It should be noted that deferasirox dispersible tablets () should be used with caution in patients with reduced liver and kidney function, elderly patients, pregnant and lactating women, and children under 6 years old; children under 2 years old should not use it.