恩瑞格怎么样？

The chemical name of Deferasirox () is 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid. It is an iron chelator product developed by the Swiss pharmaceutical company Novartis. It is the first oral iron anthelmintic approved by the US FDA for routine use. Deferasirox is approved for use in patients with iron accumulation caused by long-term blood transfusions (such as thalassemia or other rare anemias). , suitable for children over two years old and adults. The therapeutic effect of Enrig has always been of concern to patients. How about Enrig?

The therapeutic effect of Enrig is worthy of recognition. Enrig is an oral active chelating agent that is highly selective with iron. Enrig is a ligand with three protrusions that binds iron with high affinity in a 2:1 ratio. Although deferasirox has a very low affinity for zinc and copper, the concentrations of these trace metals in the serum still decrease to varying degrees after administration. Therefore, Enriga can be mainly used to treat chronic iron overload caused by frequent blood transfusions in patients with β-thalassemia older than 6 years old.

Medical companions remind: In order to ensure the efficacy of Enrig, scientific and rational use of drugs is undoubtedly very important. Therefore, for patients, it is recommended that Enrig be used under the guidance of a doctor. It is recommended for patients with iron accumulation, such as those who require long-term blood transfusion (blood transfusion volume up to 100ml/kg) and whose serum ferritin exceeds 1000ug/liter. ; Corresponding to body weight, it is initially recommended to take a daily dose of 20 mg/kg of deferasirox. Depending on the improvement of serum ferritin indicators, patients may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day. Taking deferasirox () may cause rash. Generally, the rash will disappear automatically without the need to adjust the dose or stop the medication. If the condition is serious or persistent, the medication should be stopped.