恩瑞格治疗效果怎么样呢？

Iron overload increases the risk of infection, endocrine system damage, vital organ dysfunction, AML transformation in MDS patients, and shortens survival. Iron chelators are currently the mainstream treatment for iron removal. Among them, (Deferasirox) is easy to administer, significantly reduces ferritin levels, and has a definite effect in protecting important target organ systems such as the liver, heart, and endocrine system. It is currently the preferred option for iron removal treatment.

How effective is Deferasirox?

The study screened and optimized the formulation of Deferasirox dispersible tablets with disintegration time limit and 30 Minute cumulative dissolution was used as the evaluation index, and the dosage of diluent microcrystalline cellulose (MCC) and lactose, the internal mass ratio of disintegrant cross-linked povidone (PVPP), and the dosage of cosolvent sodium dodecyl sulfate (SDS) were used as factors. The L9 (34) orthogonal test table was used to design the test plan, and the deferasirox dispersible tablet formula was screened and the formula was verified. The results showed that the optimized prescription was 12.5% ​​MCC, 27.5% lactose, 18% PVPP (internally added), and 1.0% SDS. In the verification test, deferasirox dispersible tablets completely disintegrated within 120 s, with an average 30-minute cumulative dissolution of 86.0%, which has great advantages over ordinary tablets. It can be seen that the dissolution rate, disintegration time and other indicators of Deferasirox dispersible tablets prepared according to this prescription meet the requirements.

The therapeutic effect of Deferasirox dispersible tablets is worthy of recognition. Deferasirox dispersible tablets have 3 protruding ligands that bind iron with high affinity in a ratio of 2:1. Although Deferasirox has a very low affinity for zinc and copper, the concentrations of these trace metals in serum decreased to varying degrees after administration.

(Deferasirox) The common starting dose is 20mg/(kg·d). If there is a large amount of blood transfusion, the iron increase is >0.5mg/(kg·d) or the iron load before treatment is high, the recommended dose is 30mg/(kg·d). The iron increase is <0.3mg/kg, and 10-15mg/kg/d is enough to control the disease.