瑞士诺华的地拉罗司效果如何

The case data of TDT combined with iron overload and treated with (DFX) or deferoxamine (DFO) in June 2015 were retrospectively analyzed. Fifty-eight children in the DFX group were treated with DFX 20~35 mg/(kg·d), and 27 children in the DFO group were treated with DFO 25~45 mg/(kg·d), 5 days a week. The patients were followed up for 1 year since taking the medication, and serum ferritin (SF) levels, liver and kidney function, and blood routine were measured every 3 to 6 months.

Results: There was no statistically significant difference in the median age, average iron intake rate and pre-treatment SF between the two groups of children. After 6 months of follow-up, the mean SF decreases in the DFX group and DFO group were 168 (-2 650, 7 254) ng/mL and 170 (-260, 599) ng/mL respectively (P>0.05). The decrease in SF in the DFX group was positively correlated with dose (P<0.05). After 7 to 12 months of follow-up, the mean SF decreases in the DFX group and the DFO group were 212 (-370,795) ng/mL and -1 330 (-2454,-206) ng/mL respectively (P<0.05). Conclusion: DFX has advantages over DFO in treating TDT, and the maximum dose within the tolerance range should be used. DFX can stabilize SF and should be used long-term.

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