兰索拉唑治疗胃溃疡效果如何？作用机制是什么？

Lansoprazole was developed by Takeda and was approved for marketing by the U.S. Food and Drug Administration (FDA) on May 10, 1995, under the trade name Prevacid. Lansoprazole is a proton pump inhibitor that acts and is similar to omeprazole and is used to treat peptic ulcers and other conditions where inhibition of gastric acid secretion may benefit. It is often administered orally in the form of capsules, dispersible tablets or suspensions containing enteric-coated granules. The usual regimen is once a day, before breakfast. Intravenous dosage forms are also available.

Study the clinical therapeutic effect of lansoprazole tablets in gastric ulcer disease. Methods: 60 patients with gastric ulcer who received treatment were taken as the research subjects, and they were divided into the control group and the observation group using the digital random method. The control group was orally administered omeprazole, and the observation group was orally administered lansoprazole tablets. Both groups of patients were given combined treatment with amoxicillin and metronidazole, and the clinical efficacy of the two groups of patients was compared and analyzed. Results After 2 weeks of treatment, the total clinical treatment effectiveness rate of the patients in the observation group was 93.33%, which was significantly higher than the 70.00% in the control group (P<0.05). The positive rate of Hp detection in the observation group was 6.67%, which was significantly lower than the 36.67% in the control group (P<0.05). The difference was significant and statistically significant. Conclusion In the treatment of gastric ulcer, lansoprazole tablets can improve the ulcer healing rate, have significant clinical efficacy, and can be promoted and applied in clinical practice.

Lansoprazole tablets have a specific inhibitory effect on gastric acid that causes ulcers:

1. It has a significant inhibitory effect on basic gastric acid secretion and gastric acid secretion caused by all irritants (such as histamine, carbamylcholine, etc.). The degree of inhibition is obviously dependent on the concentration of the product.

2. It has strong acid-suppressing effect and is obviously better than H2 receptor blockers.

3. The acid-suppressing effect lasts for a long time. This is because the proton pump cannot be restored once it is inactivated. It needs to wait for the formation of a new proton pump before its acid secreting effect can be restored.

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