【药效PK】兰索拉唑和奥美拉唑的区别？哪个效果好？

What is the difference between lansoprazole and omeprazole? Which one works better? Lansoprazole is a new proton pump inhibitor after omeprazole. Their chemical structures are very similar, and they are both benzimidazole derivatives. The difference from omeprazole is that the former has one more fluorine on the pyridine ring. Both proton pump inhibitors are lipophilic and can easily penetrate cell walls. Because their molecular structures contain pyridine rings, they are weakly alkaline and have affinity for the acidic environment of mural cells.

The bioavailability of lansoprazole is more than 30% higher than that of omeprazole, and its lipophilicity is also stronger than that of omeprazole. Therefore, under acidic conditions, it can quickly pass through the parietal cell membrane and transform into sulfenic acid and sulfenyl derivatives to exert its medicinal effect. Its antibacterial activity against HP is 4 times that of omeprazole. It has a significant inhibitory effect on basal gastric acid secretion and gastric acid secretion caused by all irritants (such as histamine, carbamylcholine, etc.), and the degree of inhibition is obviously dependent on the concentration of the product. It has a strong acid-suppressing effect and is significantly better than H2 receptor blockers.

Compare the effects of lansoprazole and omeprazole in the treatment of gastric ulcers. Methods: 106 patients with gastric ulcer were selected and randomly divided into study group and control group, with 53 cases in each group. The control group was given omeprazole capsules 20 mg, and the research group was given lansoprazole capsules 30 mg. After taking it continuously for 4 weeks, the efficacy, adverse reactions, Hp eradication, and follow-up recurrence rates of the two groups were compared. Results: The overall effective rate and Hp eradication of the study group were better than those of the control group (P<0.05). There was no significant difference in adverse reactions and follow-up recurrence rates between the two groups (P>0.05). Conclusion: The clinical efficacy of lansoprazole in the treatment of gastric ulcer is satisfactory and superior to omeprazole.

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