埃索美拉唑的作用与功效价格

The effects and efficacy of esomeprazole:

The main component of esomeprazole is esomeprazole magnesium. The drug reduces gastric acid secretion through a specific targeting mechanism. It is concentrated in the high-acid environment of parietal cell acid secretion microtubules and converted into an active form, thereby inhibiting H+/K+-ATPase (proton pump), inhibiting both basal gastric acid secretion and stimulated gastric acid secretion.

The absorption of ketoconazole and itraconazole may be reduced during esomeprazole therapy. When used concomitantly with diazepam, citalopram, imipramine, clomipramine, phenytoin, etc., the dose of these drugs may need to be reduced. Therefore, it is recommended to monitor phenytoin plasma concentrations when esomeprazole is coadministered or discontinued during phenytoin therapy. No incompatibility.

Esomeprazole is suitable for:

1. Gastroesophageal reflux disease (CERD): erosive reflux esophagitis, 40 mg/d, for 4 to 8 weeks; after cure, 20 mg/d maintenance treatment to prevent recurrence. If there are only symptoms but no inflammation, 20 mg/d is given. After the symptoms are relieved, the drug can be taken as needed, 20 mg/d.

2. Eradication of Helicobacter pylori in peptic ulcer disease is the basis for long-term remission of peptic ulcer disease. For duodenal ulcer, 20 mg is used in combination with two antibiotics, mostly amoxicillin 1.0 and clarithromycin 0.5, 2 times/d. The treatment course is 7 days. For patients with active ulcer disease, single drug treatment is usually given to ensure symptom relief and ulcer healing. The ulcer healing rate was 90% after 4 weeks. As effective as omeprazole in relieving upper abdominal pain.

3. For gastrinoma (Zerollis-Ellison syndrome), the recommended starting dose is 40 mg/d. Then, the dose should be adjusted individually and the course of treatment determined based on clinical manifestations.

4. Use triple combination with antibiotics to eradicate Hp: Nexium 20mg amoxicillin 1g and clarithromycin 500mg, 2 times a day for 7 days, the eradication rate is 89%.

Price of esomeprazole: According to Medical Companion Travel, the Japanese version of esomeprazole is about 1,900, and the Indian version is about 500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.