吃阿普斯特配合什么外用药效果好？

Taking Apremilast can be combined with some emollients, glucocorticoids, retinoic acid and other topical drugs under the guidance of a doctor, which can improve the local treatment effect. Common drugs such as hydrocortisone butyrate cream, calcipotriol ointment, retinoic acid cream, etc. should be selected according to your own situation.

Apremilast Drug Overview

It is an oral small molecule drug that specifically inhibits phosphodiesterase-4 enzyme and regulates the immune system by increasing intracellular cyclic adenophosphate (cAMP) levels and inhibiting the production of IL-2&8, interferon-γ and tumor necrosis factor. It is approved by the FDA for the treatment of moderate to severe plaque psoriasis, psoriatic arthritis, and Behcet's disease oral ulcers.

In contrast to biologics that target single cytokines, apremilast, which degrades phosphodiesterase 4 (PDE 4), interferes with cyclic antimicrobial peptides involved in intracellular signal transduction, controlling the balance of pro- and anti-inflammatory signals.

What external medications can Apremilast be used with?

1. Emollients:

For example, vitamin E milk, Qingpeng ointment, etc., have a moisturizing effect and can relieve dry skin problems.

2. Glucocorticoids:

For example, hydrocortisone butyrate cream, mometasone furoate cream, etc. These drugs have the effect of inhibiting cytokines and anti-inflammatory, and are the most commonly used topical drugs for the treatment of psoriasis.

3. Vitamin D3 derivatives:

For example, calcipotriol ointment can inhibit epidermal proliferation and promote keratinocyte differentiation.

4. Vitamin A acid:

Tretinoin A acid cream, for example, can inhibit local inflammation.

5. Calcineurin inhibitors:

Such as tacrolimus ointment, pimecrolimus cream, etc. These drugs have anti-inflammatory effects.

Effects of Apremilast Alone

The efficacy of Apremilast in moderate to severe psoriasis has been confirmed in the pivotal trial, with a PASI-75 response rate of 30% at week 16, and this effect continued through week 52.

Apremilast has also shown significant efficacy in site-specific diseases such as palmoplantar, nail and scalp psoriasis, improving patients' quality of life and achieving rapid improvement in pruritus.

Findings from some real-world series suggest that PASI-75 responses in patients with lower baseline PASI may be higher than those observed in pivotal trials, reinforcing the importance of using absolute PASI scores rather than relative PASI indices as markers of treatment success in this setting.

Apremilast has demonstrated favorable safety and tolerability in both clinical trials and clinical practice series.

Summary

Apremilast has certain efficacy in the treatment of psoriasis and psoriatic arthritis. If the patient wants to cooperate with topical medication during treatment, he should consult a doctor in advance and make a choice under the guidance of a doctor based on his or her own situation. It must not be used privately.

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