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Roflumilast cream can be purchased through hospital pharmacies, pharmacies, medical service institutions, consulting patients, adding patient groups, etc. You can choose the appropriate purchase method according to your own situation.

Marketing information

On April 28, 2023, roflumilast cream has received regulatory approval from Health Canada for the topical treatment of plaque psoriasis, including the treatment of intertriginous psoriasis in individuals 12 years of age and older.

On December 15, 2023, the U.S. Food and Drug Administration approved roflumilast cream for the treatment of seborrheic dermatitis in individuals 9 years of age and older.

As of January 2024, roflumilast cream has not yet been launched in China.

Indications for Roflumilast Cream

It is a topical phosphodiesterase-4 (PDE-4) inhibitor recently approved for the treatment of plaque psoriasis and is also indicated for use in the intercartilage area. The active ingredient roflumilast inhibits PDE-4, thereby suppressing the pro-inflammatory immune response in psoriatic lesions.

Where to buy roflumilast cream

1. Hospital pharmacies:

You can go to countries where roflumilast cream is already on the market, such as the United States. You can go to a hospital in the United States and get a medical prescription. You can buy roflumilast cream directly in the hospital pharmacy.

2. Pharmacies:

You can purchase Roflumilast cream in pharmacies in listed countries such as the United States. A medical prescription is also required before purchase.

3. Medical service institutions:

Domestic medical service institutions may sell roflumilast cream. You can consult customer service personnel to learn more. After placing an order, you can obtain roflumilast cream through international direct mail.

4. Consult with patients:

If you know psoriasis patients, you can directly ask them to help you purchase, or you can consult their purchasing methods, and you can also refer to this purchasing method to purchase.

5. Add a patient group:

You can add a reliable psoriasis patient group on the Internet, and then ask in the group chat whether anyone has purchased roflumilast cream and how to purchase it, so as to exchange drug purchasing experiences.

The price of roflumilast cream

The current reference price of ZORYVE (roflumilast cream) is between 12,420$-1,500$, which is relatively expensive and needs to be purchased at your own expense. The price will also change due to international exchange rate differences and other factors, and the actual price shall prevail.

Efficacy of Roflumilast Cream

Two Phase 3 clinical trials demonstrated the efficacy of once-daily roflumilast cream for the treatment of plaque psoriasis in patients 12 years of age and older. At week 8, an investigator global assessment score of 0 or 1, a 2-grade improvement from baseline, the primary efficacy endpoint, was observed in 39.1% of patients and in 6.6% of patients. After 8 weeks of treatment with roflumilast cream, the percentage of patients with plaque psoriasis who achieved a successful Investigator Global Assessment (IGA) was 42.4%.

Common adverse events reported during treatment include diarrhea, headache, insomnia, nausea, administration site pain, upper respiratory tract infection, and urinary tract infection.

Instructions for use

Apply roflumilast cream to the affected area once a day and rub it in thoroughly. Wash hands after application, unless used to treat hands. Roflumilast cream is for topical use only and is not intended for ocular, oral, or vaginal use.

(Note: The above dosage and administration reference are from the U.S. FDA drug instructions. The usage and dosage are for reference only. Specific needs are subject to medical advice)

Summary

Roflumilast cream is suitable for the treatment of psoriasis. If medication is required, it should be used under the guidance of a physician. Do not self-administer.

References:

Gupta AK, Ravi SP, Vincent K, Abramovits W. ZORYVETM (Roflumilast) Cream: A Topical Phosphodiesterase-4 Inhibitor for the Treatment of Psoriasis. Skinmed. 2023 Nov 10;21(5):357-359. PMID: 37945365.

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