绥美凯适应症

It is doptabalamid tablets. Its specification is 50mg/600mg/300mgx30 tablets. It is suitable for the treatment of human immunodeficiency virus infection. It can be used by adults and teenagers over 12 years old, but please note that the patient's weight is at least 40kg. HIV is an extremely scary virus. After being infected with AIDS, many people worry about whether they will die soon. The fear that AIDS brings to patients is terrifying. Suimeikai is a compound medicine. Each tablet contains dolutegravir sodium 50mg, abacavir sulfate 600mg, and lamivudine 300mg. It is suitable for treating HIV adults and patients over 12 years old. Among them, the dolutegravir component can block the strand transfer of DNA integration through binding to the integrase active site, which is one of the key steps for HIV replication, thereby inhibiting HIV integrase in the body.

Judging from a large number of clinical trial data, DTG has a low discontinuation rate due to adverse drug reactions (ADR) or virological failure, which are 5.8% and 0.5% respectively. The ADR drops significantly after one year of taking the drug. The most common adverse reactions are gastrointestinal dysfunction, mental disorders and neurological disorders, but the adverse reaction rates are less than 1.5%. From the comparison with patients who failed the first-line regimen of RAL (Ascent) and EVG (Evitegravir), the other two integrase inhibitors, the number of drug-resistant mutations in Trimeq is significantly less than that of the other two drugs, making it less likely to develop drug resistance. In the real world, antiviral treatment-naïve patients treated with DTG have a lower proportion of central nervous system-related (CNS) adverse events than the four drugs RAL (Ascent), DRV/r (darunavir), EFV (efavirenz) and ATV/r (atazanavir). Therefore, the drug safety of Suimeike, which is based on DTG integrase inhibitors, has proven to be controllable. Generally speaking, it has four main advantages: 1. Excellent efficacy and significant viral suppression effect; 2. The three drugs are equivalent, and both newly-treated and previously treated patients have high drug resistance barriers, which is not easy to lead to drug resistance; 3. It is easy to take, only needs to be taken once a day, and there is no need to consider food effects; 4. The drug has low side effects and good tolerance, and the discontinuation rate due to drug side effects is low; 5. The metabolic pathway has few interactions with other drugs.