绥美凯用药时间需要固定吗？

It is a drug for the treatment of AIDS. It is currently the only three-in-one compound drug containing dolutegravir (DTG). Does the medication time of Suimeikai need to be fixed?

The method of use of Suimeikai is to take one tablet at a time, once a day, and take it at a fixed time every day. When the weight is less than 40kg, this drug generally cannot be used. This drug is a fixed-dose preparation and the dosage cannot be reduced. However, this dosage of doptabalamid tablets cannot be used on patients who need to adjust the dosage.

Sui Meikai’s missed dose:

If the patient misses a dose of Suimei Kai and there are more than 4 hours before the next dose, Sui Meikai should be taken as soon as possible. If the next dose is less than 4 hours away, patients should not take the missed dose and simply resume their usual dosing schedule.

Elderly patients taking Suimeikai:

There are limited data on the use of dolutegravir, abacavir, and lamivudine in patients aged ≥65 years, and there is no evidence that older patients require different doses than younger adults. Taking into account age-related changes, such as decreased renal function and changes in hematological parameters, special caution is recommended when administering the drug in this age group.

Use SuimeiKai for kidney damage:

Patients whose creatinine clearance rate is less than 50mL/min are not recommended to take Suimeikai.

Use SuimeiKai for liver damage:

Abacavir is primarily metabolized by the liver. There are no clinical data in patients with moderate or severe hepatic impairment, therefore, use of Trimax is not recommended unless deemed necessary. For patients with mild hepatic impairment (Child-Pugh score 5-6), close monitoring is required, including monitoring of abacavir plasma levels if feasible.

Use of Suimeikan in children:

Safety and effectiveness have not been established for use in children under 12 years of age. No data yet.

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