维利西呱作用机制是什么,安全性高吗？

Heart failure (HF) is a severe and terminal stage of various cardiovascular diseases. It is a group of syndromes caused by impaired ventricular filling or ejection function. Its clinical manifestations include limited activity tolerance, dyspnea, pulmonary congestion, and peripheral edema. The prevalence of HF in my country has obvious regional, ethnic and age differences. According to the 2018 edition of the "Blue Book on the Current Situation of Heart Failure Prevention and Treatment in China",

Currently, there are 6.5 million to 8.75 million HF patients over 60 years old in my country. (Trade name: Verquvo) is a soluble guanylate cyclase (sGC) agonist that promotes the generation of cyclic guanosine monophosphate (cCMP) independently of nitric oxide (NO) and synergistically with NO, improving myocardial and vascular function. It was jointly developed by Merck and Bayer and was approved by the U.S. Food and Drug Administration in January 2021 for the treatment of adult chronic HF patients with symptomatic ejection fractions less than 45%. So, what is the mechanism of action of vericiguat, and is it highly safe?

What is the mechanism of action of Vericiguat?

Vericiguat is a new type of oral, soluble guanylyl cyclase agonist. Its mechanism of action is mainly to directly stimulate soluble guanylyl cyclase through a binding site unrelated to nitric oxide, and stabilize the combination of nitric oxide and the binding site, making sGC sensitive to endogenous nitric oxide. By enhancing the L-ARG-NO-sGC-cGMP signaling pathway, it improves myocardial and vascular function, prevents or even reverses left ventricular hypertrophy and fibrosis, slows down ventricular remodeling, and reduces ventricular afterload through systemic and pulmonary vasodilation, thereby exerting a therapeutic effect on heart failure through the above mechanisms.

Is Vericiguat safe?

According to relevant clinical trials, the side effects of vericiguat are generally hypotension and anemia. It can be seen that the safety of this drug is very high.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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