维利西呱的适应症,用法用量,注意事项及价格？

VERQUVO) is indicated for heart failure. The recommended starting dose is 2.5 mg once a day, taken with food. Pay attention to embryo-fetal toxicity when using it. It is understood that veliciguat is currently sold in German and Japanese versions, with three specifications.

About Veliciguat

Veliciguat is a treatment drug for chronic heart failure (CHF) launched by Bayer in early 2021 after a lapse of 7 years. Its target is still an sGC agonist. Veliciguat has improved pharmacokinetic properties, increased metabolic stability, extended half-life, and can be taken orally once a day, thus expanding its indications. As a new anti-heart failure drug, Vericiguat provides a new option for the treatment of CHF and is known as a new milestone in the history of heart failure treatment. It can clinically significantly improve the congestion symptoms and prognosis of patients with heart failure and has been unanimously recognized by European and American guidelines.

Vericiguat usage and dosage

1. Starting dose and administration method

The recommended starting dose of VERQUVO is 2.5 mg, once a day, with food.

Patients should take the medication according to the recommended dosage and method under the guidance of a doctor.

2. Gradual increase in dose

(1) Every approximately 2 weeks, the dose of VERQUVO will be doubled to gradually reach the target maintenance dose of 10 mg once daily as tolerated by the patient.

(2) During the dose increase process, patients should pay close attention to their own tolerance and drug effects, and maintain good communication with their doctors.

3. Treatment when the tablet cannot be swallowed

For patients who cannot swallow the entire tablet, VERQUVO can be crushed immediately before administration and mixed with water before taking.

When crushing and mixing medications, patients should be sure to use clean utensils and the right amount of water to ensure correct medication dosage and even mixing.

Vericiguat

1. Embryo-fetal toxicity: According to data from animal reproduction studies, VERQUVO may cause harm to the fetus when used in pregnant women. Inform women of reproductive potential of potential risks to the fetus. Take a pregnancy test before starting treatment. Advise females of reproductive potential to use effective contraception during treatment with VERQUVO and for at least one month after the final dose.

2. VERQUVO is contraindicated in patients using other soluble guanylate cyclase (sGC) stimulators at the same time. This is because simultaneous use of multiple sGC stimulators may increase the patient's risk of hypotension. Before using VERQUVO, patients should inform their doctor in detail about other medications they are taking to avoid drug interactions.

3. VERQUVO is contraindicated during pregnancy. According to the drug description, VERQUVO is listed as a contraindicated drug during pregnancy. Women using VERQUVO should consult their doctor immediately if planning to become pregnant or during pregnancy to seek other safe treatment options or medication options.

The price of Vericiguat

It is understood that Vericiguat is currently on sale in German and Japanese versions, with three specifications:

1. German version of Vericiguat from Bayer Pharmaceuticals in Germany

(1) Specifications: 28 pills per box, 2.5mg per pill, reference price is about $2,500.

(2) Specifications: 98 pills per box, 5 mg per pill, reference price is about 4665$.

(3) Specifications: 98 pills per box, 10mg per pill, reference price is about $4,700.

2. Japanese version of Vericiguat

(1) Specifications: 100 pills per box, 2.5mg per pill, reference price is about $1,100.

(2) Specifications: 100 pills per box, 5 mg per pill, reference price is about 1850$.

(3) Specifications: 100 pills per box, 10mg per pill, reference price is about 3010$.

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