一盒依普利酮多少钱呢？

(eplerenone) binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

Eplerenone can be used for congestive heart failure after acute myocardial infarction. Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for congestive heart failure after acute myocardial infarction.

The dosage for treating high blood pressure in adults is as follows: eplerenone can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily, Maintenance dose: 50 mg orally once or twice daily, Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

In 2002, eplerenone, developed by Pfizer, was first launched in the United States. It is mainly used clinically to treat hypertension. In 2003, the FDA approved it for the treatment of heart failure after acute myocardial infarction.

Medical Travel learned that the price of 25mg-30 tablet bottles/box in the United States in 2019 was around US$118.71. However, the price of eplerenone 50mg*100 tablets from India's Lupine Pharmaceuticals is around RMB 500, which is very cheap. Patients can purchase it through Medical Companion Travel.