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Essential hypertension is often accompanied by activation of the renin-angiotensin-aldosterone system (RASS) and secondary hyperaldosteronemia. Therefore, aldosterone receptor antagonists are an important class of drugs for the treatment of essential hypertension. As the first selective aldosterone receptor antagonist, it has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of hypertension. The "China Hypertension Prevention and Treatment Guidelines 2010" also proposed eplerenone as one of the main antihypertensive drugs.

The combination of eplerenone and enalapril can significantly reduce left ventricular weight, and the addition of hydrochlorothiazide and amlodipine can further reduce it. Previous studies have confirmed that left ventricular mass index is associated with event-free survival. In studies on patients with diabetes mellitus and proteinuria, both eplerenone and enalapril can reduce systolic blood pressure and diastolic blood pressure, but eplerenone reduces the urinary albumin/inosine ratio UACR more significantly than enalapril.

The EPHESUS trial showed that for patients with left ventricular ejection fraction (LVEF) <40% and heart failure within 3 to 14 days after myocardial infarction, the addition of eplerenone to standard treatment can reduce all-cause death by 15%, primary combined endpoint events (cardiovascular death or hospitalization for cardiovascular events) by 17%, and sudden cardiac death (sudden cardiac death) by 21%. cardiac death, SCD).

Eplerenone was approved by the U.S. FDA in 2002. However, eplerenone is currently only available in Hong Kong and Taiwan, which means that eplerenone has not yet been launched in my country.

Since eplerenone has not yet been launched in China, and the price of the original drug developed by Pfizer is generally higher, more and more patients are beginning to buy generic eplerenone drugs produced in India.

The Indian version is 50mg*100 tablets, produced by Lupine Pharmaceuticals in India. The price is equivalent to RMB 500, which is very cheap. Patients can purchase it through Medical Companion Travel.