依普利酮在国内的价格

It is a new type of selective aldosterone receptor antagonist. The pure product is white or off-white crystal. It has stronger aldosterone antagonism than spironolactone, and has extremely low affinity for androgen and progesterone receptors. It has few adverse reactions and has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has fewer adverse reactions and good tolerance. It is a good alternative drug to spironolactone.

  Subgroup analysis of the EPHESUS study also showed that the effect of eplerenone on reducing overall mortality was more obvious in patients with hypertension. A comparative study on the efficacy and tolerability of 499 patients with grade 1 or 2 hypertension who were randomized to receive enalapril or eplerenone showed that at 6 months, enalapril was as effective as eplerenone in reducing systolic blood pressure (14.5 mmHg for eplerenone; 12.7 mmHg for enalapril: P=0.199) and diastolic blood pressure (11.2 mmHg for eplerenone; 11.3 mm for enalapril). Hg; P=0.910). After 12 months, the two groups were also similar (eplerenone -16.5/-13.3mmHg; enalapril -14.8/-14.1mmHg, P values ​​0.251 and 0.331 respectively). Dropout due to adverse events (7.9% for eplerenone and 9.3% for enalapril at 6 months) and treatment failure rates were also equal (23.3% for eplerenone and 22.8% for enalapril at 6 months). About 2/3 of the patients in each group achieved normal blood pressure at 6 months with the above single treatment. In the eplerenone group, the reduction in blood pressure was independent of renin levels, unlike enalapril. Both groups could reduce proteinuria above normal levels, but the eplerenone group was more significant (-61.5% vs -25.7%; P=0.01).

Not only that, eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for congestive heart failure after acute myocardial infarction.

So what is the price of eplerenone in the country?

It has not yet been launched in the country, so there is no domestic price for eplerenone. However, the price of eplerenone 50mg*100 tablets from India's Lupine Pharmaceuticals is around RMB 500, which is very cheap. Patients in need can purchase it through Medical Companion Travel.